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What should my health care professional know before I take Kaletra?

Serious drug interactions can occur when certain medicines are used together with lopinavir and ritonavir. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.
Some medicines can cause unwanted or dangerous effects when used with Kaletra. Your doctor may need to change your treatment plan if you use any of the following drugs:

• alfuzosin;

• pimozide;

• rifampin;

• lovastatin, simvastatin;

• midazolam, triazolam;

• sildenafil (Revatio for pulmonary arterial hypertension);

• St. John's wort; or

• an ergot medicine (ergotamine, dihydroergotamine, methylergonovine).

To make sure Kaletra is safe for you, tell your doctor if you have:

• liver disease (especially hepatitis B or C);

• heart disease or a heart rhythm disorder;

• a personal or family history of Long QT Syndrome;

• pancreas problems;

• diabetes;

• low levels of potassium in your blood;

• a bleeding disorder such as hemophilia;

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• if you have ever used a protease inhibitor in the past.

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If you are pregnant, your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Kaletra on the baby.
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